LIH studies allergic reactions to peanuts

LIH studies allergic reactions to peanuts

The team tried to understand all of the different mechanisms of the immune response. The results are extremely encouraging in trying to better understand this pathology.

An innovative approach


The team tried to understand all of the different mechanisms of the immune response. The results are extremely encouraging in trying to better understand this pathology.

17 million was, in 2020, the number of Europeans affected by a peanut allergy. Between 2005 and 2015, the number of people suffering from this condition doubled and it has been climbing ever since. However, even today, the cause of this evil remains unknown. What we do know, however, is that the reactions can be quite mild but can also, in some cases, lead to serious complications that can go as far as death.

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In other words, the problem is deep and deserves our full attention. The Luxembourg Institute of Health (LIH) was not mistaken. After revealing the results of its pioneering study on pollutants in children’s hair, the institute now wants to tackle peanut allergies.

More concretely, the LIH has deciphered the real-time immune response of subjects suffering from these allergies. “This survey, the first of its kind, has identified biological markers in children that could help the clinical world assess how and under what circumstances a child might respond, with future implications for better treatments and prevention strategies. “, notes the institute in a press release.

Treatments are sorely lacking

An innovative approach therefore when, as explained above, treatments are lacking. “Therapeutic options are quite limited, which means that health systems are under increasing strain and that there is an urgent need for new therapeutic and diagnostic solutions,” recalls the LIH. “Food allergies have skyrocketed over the past two decades and this increase in prevalence is not about to stop. Initially, it was mainly a pediatric disease, but today more and more adults are also affected,” adds Dr. Annette Kuehn, from the Department of Infections and Immunity. .

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The hay fever season resumed its rights a few days ago, the opportunity to come back to this illness from which 20% of the total population of the Grand Duchy suffers.

In the new study led by the latter and Professor Markus Ollert, in close collaboration with Dr. Morel-Codreanu, medical partner of the National Allergology-Immunology Unit of the Luxembourg Hospital Center (CHL), the objective is to search for different biological markers in the blood of children suspected of being allergic to peanuts, throughout a controlled exposure to peanuts. “In doing so, the researchers’ goal is to identify markers that would allow them to predict how an individual might respond to peanut exposure. These predictions could include not only whether or not a child reacts to it, but also with what symptoms and based on how much peanut. It could therefore be a powerful diagnostic tool for the clinical world, removing the need for laborious and expensive approaches.”

Proven tests on 26 children

A total of 26 children with an average age of seven and a half years were evaluated, along with seven peanut-tolerant adults included as controls. Based on the results, the team was able to draw extremely encouraging conclusions. “First, from the immune signatures of the volunteers, it was possible to distinguish between people who did or did not have an allergic response. In the case of an allergic response, it is generally found that specific blood immune cells tend to be fewer in number, but express more “localization markers”, indicating that these cells are better equipped to enter affected tissues and cause symptoms,” the study announces.

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Researchers from the Luxembourg Institute of Health have just found a treatment to reduce intransigence reactions to the proximity of felines. Attention, mandatory injection.

A second success for the researchers was the ability to identify groups of children who tolerated higher or lower doses of peanuts before developing an allergic response, based on variations in the abundance of certain white blood cells and d other key immune cells. “The results even made it possible to determine whether the symptoms experienced were mainly related to the skin or the gastrointestinal tract. This type of analysis could therefore prove to be extremely useful for the diagnosis and monitoring of allergic reactions”.

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