Researchers from Tufts University in the United States present recent findings that support the hypothesis that Alzheimer’s disease may be triggered by a virus. The strain in question is very common since it is the varicella zoster virus (VZV)
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To explain these observations,. Factors seem to have an important role in sporadic cases of Alzheimer’s, the most frequent, but a dysregulation of the synthesis of amyloid proteins or the intervention of a This term encompasses a variety of very different species, whether they are prokaryotes ( bacteria) or eukaryotes (yeast, algae)….” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/1/7/5/1753fd009d_50035172_escherichia-coli-micro-organism-ars -wikimedia-03.jpg” data-url=”https://news.google.com/sante/definitions/biology-micro-organism-6183/” data-more=”Read more”> – a virus most of the time – could also have an implication.
Experiences in vitro on cultured neurons
A team from Tufts University, in the United States, presents results falling within the framework of the “viral hypothesis” on the origin of Alzheimer’s disease. The latter states that a virus
Like all viruses of the Herpesviridae family and more specifically of the Varicellovirus genus, the…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/7/9/7/ 79777c7579_50035994_vzv-wiki.jpg” data-url=”https://news.google.com/health/definitions/medicine-virus-varicella-shingles-7948/” data-more=”Read more”> that triggers inflammation waking up the HSV-1 virus in the brain explains Dana Cairn functions
Cairns are used to mark paths in arid, rocky areas or on glaciers. They can…” data-image=”https://cdn.futura-sciences.com/buildsv6/images/midioriginal/5/c/3/5c360d42ac_50038920_cairn-summit-bugmonkey-flickr.jpg” data-url=” https://news.google.com/sciences/definitions/homme-cairn-12817/” data-more=”Read more”> first author of .
To corroborate this hypothesis, they infectedhuman neural cells with the two viruses and looked for the presence of markers specific to Alzheimer’s: amyloid plaques and Tau aggregates, gliosis (proliferation of in the brain) and neuroinflammation. Their results show that the VZV virus alone does not cause the formation of amyloid plaques and Tau aggregates, like HSV-1, but neuroinflammation and gliosis. This suggests, according to scientists, an indirect action of the VZV virus. In addition, they observed that infection of cells, in which HSV-1 is dormant, by the VZV virus reactivates the latter and causes changes typical of Alzheimer’s. ” It’s a double punch of two viruses that are very common and generally harmless, but lab studies suggest that if further exposure to VZV awakens dormant HSV-1, it could cause problems. “says Dana Cairns.
These experiments alone are not robust enough to confirm a causal link between Alzheimer’s disease and the VZV and HSV-1 viruses, even if the observations point in this direction. Moreover, the different hypotheses being studied on the origin of Alzheimer’s disease are not necessarily mutually exclusive. Viral infection could be a factor to consider in Alzheimer’s disease, among others.
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