Africa facing the childhood cancer challenge: ambitious goals Daily Sabah

L’Afrique au défi du cancer de l’enfant : des objectifs ambitieux

Pediatric oncology is a relatively young medical specialty but which has experienced particularly rapid development throughout the last decades. This is due in particular to the very significant progress made in the care of these children and the considerable improvement in recovery rates observed over the past thirty years.

However, this progress has only affected a portion of the world’s children, mainly in Europe and North America, leaving aside 80% of the world’s pediatric population, including that of the African continent in particular. While it is now 80% in high-income countries, the cure rate in low- and middle-income countries remains at 10-40%, with exact figures difficult to know.

Each year, it is estimated that 400,000 children are affected by cancer worldwide, but while only 3% of them escape diagnosis in Europe and North America, this figure reaches 57% in West Africa. In other words, of the 6 to 7 million children likely to be affected by cancer between 2015 and 2030, 2.9 million of them, a large part of them in Africa, will die from lack of having been diagnosed.

Different cancers depending on the population

Leukaemias, lymphomas and tumors of the brain and bone marrow are the most common cancers worldwide in children under 16 years of age.

Nevertheless, this distribution varies according to the country, depending in particular on the number of cancers actually diagnosed (technical platform often insufficient in the countries of the South) and genetic and environmental factors (example of Burkitt’s lymphoma, endemic in Africa and rather sporadic in the northern country).

Clearly, the fight against childhood cancers today constitutes a real challenge for low- and middle-income countries, and more specifically for many African countries: 22 of the 25 poorest countries in the world are in Africa and have an average GDP per capita of €558 (for comparison, GDP per capita in France will be €39,500 in 2021). In Togo, for example, total health expenditure was evaluated in 2012 at around 210 million euros per year, or around €40 per year per inhabitant; in France, in 2019, it was estimated at 208 billion euros per year, or €3,102 per year per inhabitant.

How to improve these results and ensure that “African children can be treated successfully in their country by African teams”, as Professor Jean Lemerle, founder of the Franco-African Pediatric Oncology Group (GFAOP) proclaimed in 2000? ? An improvement in the service offer, in clinical, diagnostic and therapeutic terms, is essential.

Improve reception and training

It presupposes an improvement in the training of medical and paramedical personnel, so that dedicated units and real multidisciplinary teams are created, which are essential for effective care of children.

It also involves better reception conditions, easier access to specific drugs (chemotherapy), to radiotherapy, to oncological surgery, but also to therapies related to supportive care, palliative care and pain. Finally, it requires support for community communication and social mobilization programs in favor of early diagnosis of children.

In 2018, WHO launched the Childhood Cancer (Cureall) initiative to provide technical support to governments to strengthen and sustain quality programs to combat this disease. This initiative can be linked to other actions carried out by various organizations such as the GFAOP or the AMCC (World Alliance against Cancer).

The latter, for example, has developed since 2016 a program to fight retinoblastoma, by training doctors in the early diagnosis and treatment of this disease in several African countries. The GFAOP, for its part, has been involved since the 2000s in the development and gradual structuring of more than 20 pediatric oncology units in French-speaking Africa.

He first worked on financing cancer drugs for the five most common cancers in Africa (Burkitt’s lymphoma, nephroblastoma, retinoblastoma, acute leukemia and Hodgkin’s lymphoma). Then between 2014 and 2018, he created in Rabat (Morocco) a DIUOP (Interuniversity diploma in pediatric oncology) for the training of paediatricians, then the Jean Lemerle Institute in Dakar (IAFOP, African Institute for training in pediatric oncology) to paramedics. In addition, in 2019, it set up an early diagnosis program aimed at combating diagnostic delays in French-speaking African countries affiliated to the GFAOP.

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Adapt to local specificities

All these programs, implemented on a multinational scale, are all essential actions for the development of pediatric oncology in Africa. They were supplemented as close as possible to the field by sharing experience between French and African pediatric oncology teams, in particular through pairings developed from 2015 by the GFAOP.

The CHU Sylvanus Olympio of Lomé, in collaboration with the CHU of Angers, has set up a five-year plan for the development of pediatric oncology taking into account the Togolese realities.
Koffi Guedenon, CHU Sylvanus Olympio, Author provided

These twinnings are indeed one of the best ways to identify the specificities of each African country, and to take into account both the needs and expectations of each country but also its capacities and priorities in terms of health. In any case, this is what we learned from the collaboration set up in 2017 between the pediatric oncology team of the CHU Sylvanus Olympio in Lomé and that of the CHU in Angers.

The two teams succeeded in drawing up, with all the institutional managers concerned, a five-year plan for the development of pediatric oncology taking into account the Togolese realities, not only in terms of health, but also in economic and political terms.

This collaboration has enabled the rehabilitation of the Pathological Anatomy laboratory of the CHU Sylvanus Olympio, an essential step in obtaining quality diagnoses. It is in this laboratory that operated tumors are studied under the microscope so that pathologists can make a precise diagnosis. This then makes it possible to offer patients the most appropriate treatments.

Ambitious goals

Other actions exist, such as the setting up of joint medical meetings (monthly videoconferences) to discuss patient care, the modernization of Internet connections, the training of doctors and paramedical staff, or the empowerment to obtain essential drugs.

All of them are part of the actions carried out by the Togolese government within the framework of the National Health Development Plan which, in the long term, should make it possible to significantly increase the population’s health coverage.

There is a long road to the WHO target of a survival rate of at least 60% for all children with cancer by 2030. However, we believe this can be achieved if that high-income States truly realize their responsibilities vis-à-vis low- and middle-income countries, and especially African countries.

But, as Thomas Sankara pointed out, it would probably be necessary, at the same time, to move away from the principle of development aid in order to establish “a real collaboration, so that all the actions undertaken constitute relevant actions […] and not permanent aid with which the populations can live only thanks to it”.

Pr. Isabelle Pellier (PU-PH) and Dr. Stéphanie Proust (PH), from the pediatric onco-haemato-immunology unit of the CHU of Angers, also contributed to the design of this article as well as to its proofreading.

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